Anti-Infective Drugs Markets

Six infectious diseases--pneumonia, tuberculosis, diarrheal diseases, malaria, measles and HIV/AIDS--account for half of all premature deaths worldwide, killing mostly children and young adults, according to the World Health Organization (WHO). Moreover, threatening pandemics such as swine flu (H1N1 influenza A virus) are adding significant pressure to already strained healthcare budgets of governments around the world.
This report TriMark Publications analyzes the anti-infective drugs market and highlights the existing and developing anti-infectives used to ameliorate infectious diseases' afflictions on humankind. Anti-infective drugs include: anti-viral therapeutics, antibiotics, anti-fungal agents and prophylactic treatments such as vaccines. Particular attention is paid to the clinical market segment and the pharmaceutical/biotechnology companies involved in anti-infective drugs with specific emphasis on each company's sales focus, product portfolio and R&D pipeline.
To date, the most successful anti-infective drugs target the human immunodeficiency virus (HIV, the virus that causes AIDS), the herpes virus (HSV-1 and HSV-2), bacterial infections and hepatitis C (HCV). A number of exciting novel anti-viral and antibiotic compounds are currently revolutionizing anti-infective drugs markets, including Truvada and Valtrex, which are anti-HIV and anti-herpes therapies, respectively. Significant resources are also being dedicated toward hepatitis A (HAV), hepatitis B (HBV) and Staph infections, including MRSA. What's more, this study will examine the existing and developing anti-infective drugs targeted at infectious diseases that continue to devastate developing countries, including: cholera, dengue fever, meningitis, rotavirus, typhoid and yellow fever.
[Studien Infos ausblenden]

1. Overview 9
1.1 Statement of Report 9
1.2 Scope of the Report 9
1.3 Methodology 10
1.4 Executive Summary 11

2. Clinical Syndromes and Therapy 20
2.1 Head and Neck 22
2.1.1 Sinusitis 22
2.1.2 Pharyngotonsillitis 23
2.1.3 Deep Neck Infections 23
2.1.4 Otitis Media and Externa 23
2.1.5 Acute Suppurative Thyroiditis 23
2.2 Eye 24
2.2.1 Conjunctivitis 24
2.2.2 Keratitis 24
2.2.3 Iritis 24
2.2.4 Retinitis 25
2.2.5 Endophthalmitis 25
2.3 Skin and Lymph Nodes 25
2.3.1 Complicated Skin and Skin Structure Infections (cSSSI) 25
2.3.2 Lymphadenitis 25
2.4 Respiratory Tract 26
2.4.1 Bronchitis 26
2.4.2 Laryngitis 26
2.4.3 Pneumonia 26
2.4.4 Influenza 28
2.4.5 Avian Bird Flu 29
2.4.6 Swine Flu 29
2.4.7 Respiratory Syncytial Virus 33
2.4.8 Tuberculosis 33
2.5 Heart and Blood Vessels 37
2.5.1 Endocarditis 37
2.5.2 Acute Pericarditis 37
2.5.3 Myocarditis 37
2.5.4 Vascular Infections 38
2.6 Gastrointestinal Tract, Liver and Abdomen 38
2.6.1 Acute Viral Hepatitis 38
2.6.2 Chronic Hepatitis 39
2.6.3 Biliary Tract Infections 40
2.6.4 Pancreatitis 40
2.6.5 Esophageal Infections 41
2.6.6 Gastroenteritis 41
2.6.7 Peritonitis 42
2.7 Genitourinary Tract 43
2.7.1 Urethritis 43
2.7.2 Prostatitis 43
2.7.3 Urinary Tract Infections 44
2.7.4 Pelvic Inflammatory Disease 44
2.7.5 Candiduria 44
2.7.6 Human Papilloma Virus 44
2.8 Nervous System 45
2.8.1 Bacterial Meningitis 45
2.8.2 Viral Encephalitis 46
2.8.3 Reye's Syndrome 46
2.8.4 Myelitis and Peripheral Neuropathy 46
2.9 Musculoskeletal System 46
2.9.1 Osteomyelitis 46
2.9.2 Polyarthritis 47
2.9.3 Bursitis 47
2.9.4 Psoas Abscess 47
2.10 Human Immunodeficiency Virus (HIV) Infection 47
2.11 Blood-borne Infections 53
2.11.1 Malaria 53
2.11.2 West Nile Virus 56

3. Anti-Infective Drugs Market 58
3.1 FDA Approvals of New Anti-Infective Therapy 60
3.2 Anti-Infective Drugs in Current Pharmaceutical Developmental Programs 68
3.3 Factors Determining Anti-Infective Drug Development 70
3.4 Pharmaceutical R&D Expenditures 70

4. Description of Anti-Infective Therapeutic Agents 72
4.1 Anti-Bacterials 72
4.1.1 Anti-Bacterial Therapeutic Agents in Current Formulation 75
4.1.1.1 B-lactam Antibiotics 76
4.1.1.2 Fluoroquinones 77
4.1.1.3 Glycopeptides 78
4.1.1.4 Macrolides 79
4.1.1.5 Oxazolidinones 80
4.1.1.6 Other Classes of Anti-Bacterial Agents 81
4.1.2 Older Classes of Antibiotics 81
4.2 Anti-Virals 82
4.2.1 Overview 82
4.2.2 Anti-Viral Therapy 82
4.2.3 Anti-Viral Market Leaders 83
4.2.4 Principles of Anti-Viral Therapy 83
4.3 Anti-Fungals 89
4.3.1 Overview 89
4.3.2 Major Classes of Anti-Fungal Therapy 89
4.3.3 Anti-Fungal Agent Resistance 90
4.3.4 Anti-Fungal Agent Market Leaders 91
4.4 Vaccines 91
4.4.1 Overview 91
4.4.2 Principles of Vaccine Therapy 93
4.4.3 Vaccine Market Leaders 94

5. Market for Anti-Infective Drugs and Vaccines 97
5.1 Molecular Diagnostics in Determining Demand 97

6. Decision-making Activity in the Anti-Infective Drugs Market 101
6.1 Net Present Value in Making Decisions to Develop and Market Antibiotics 102

7. Economics of Anti-Microbial Drug Resistance: The Persistent Need for Anti-Bacterials 104
7.1 Resistance and Antibiotic Usage 107

8. Global Market Analysis of Anti-Infective Drugs 109
8.1 Market Size 109
8.2 Market Share 109
8.3 Market Drivers 111

9. Global Market for Anti-Bacterial Therapies 112
9.1 Amoxicillin 114
9.2 Nafcillin 114
9.3 Ticarcillin 114
9.4 Imipenem 115
9.5 Ceftriaxone 115
9.6 Cefotetan 115
9.7 Dalbavancin 116
9.8 Doripenem 116

10. Global Market for Anti-Fungal Therapies 118
10.1 Amphotericin B 119
10.2 Azoles 119
10.3 Echinocandins 120
10.4 Flucytosine 120

11. Global Market for Anti-Viral Therapies 121
11.1 Antiretroviral Market 121
11.1.1 The Viral Drug Resistance Crisis 121
11.1.2 Emtricitabine 124
11.1.3 CCR5 Receptor Antagonists 125
11.1.4 Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs) 125
11.2 HCV Infections 126
11.2.1 Pegintron Alpha 126
11.2.2 Ribavirin 127
11.2.3 Boceprevir 127
11.3 Acyclovir 127
11.4 Adefovir 127
11.5 Cidofovir 128
11.6 Entecavir 128
11.7 Fomivirsen 128
11.8 Foscarnet 128
11.9 Ganciclovir 128

12. Market, Demographic and Economic Trends 129
12.1 Emerging Trends in Infectious Diseases Worldwide 129
12.2 Global Burden of Infectious Diseases 130
12.3 The AIDS Model 131
12.4 Dead-end Transmission of Zoonotic and Vector-borne Diseases 131
12.5 Environmentally Persistent Organisms 132
12.6 Old Microbes Cause New Diseases 132
12.7 Microbial Agents and Chronic Diseases 132
12.8 Remerging and Resurging Infections 133
12.9 Geographical Spread of Infectious Diseases 133
12.10 Drug-resistant Microbes 134
12.11 Opportunistic Re-emerging Infections 134
12.12 Re-emerging Zoonotic and Vector-borne Diseases 134
12.13 Influenza 134
12.14 Deliberately Emerging Infections 135
12.15 Meeting the Challenge of Emerging Diseases 135

13. Political/Legal Trends 136
13.1 AATF and Legislation 136
13.2 Bioterrorism and Biowarfare 138

14. Technological Trends 139
14.1 Anti-Microbial Discovery in the Post-genomic Era 139
14.1.1 Anti-Bacterial Polypharmacology 139
14.1.2 Topology of Targets 140
14.1.3 Designer Polypharmacology and Designing HIV-Therapies 140

15. Socio-Cultural Trends 141

16. Competitive Landscape 142
16.1 Introduction 142
16.2 Strengths and Weaknesses in Anti-Microbial Drug Discovery-Commercial 143
16.3 Strengths and Weaknesses in Anti-Microbial Drug Discovery-Academic 144
16.4 Regulatory Hurdles 144
16.5 Business Hurdles 145
16.6 Strategic Alliances, Licensing Activity, and Mergers & Acquisitions in the Anti-Infectives Landscape 146

17. Sales Performance amongst the Leading Players: Detailed Analysis of Leading Anti-Infective Players 149
17.1 GlaxoSmithKline 149
17.1.1 Overview 149
17.1.2 Sales Focus by Drug Class 149
17.1.3 Marketed Product Portfolio 150
17.1.4 R&D Pipeline Analysis 152
17.1.5 Strategic and Growth Analysis 152
17.2 Merck 153
17.2.1 Overview 153
17.2.2 Sales Focus by Drug Class 154
17.2.3 Marketed Product Portfolio 154
17.2.4 R&D Pipeline Analysis 156
17.2.5 Strategic and Growth Analysis 157
17.3 Pfizer 157
17.3.1 Overview 157
17.3.2 Sales Focus by Drug Class 158
17.3.3 Marketed Product Portfolio 158
17.3.4 R&D Pipeline Analysis 160
17.3.5 Strategic and Growth Analysis 161
17.4 Novartis AG 161
17.4.1 Overview 161
17.4.2 Sales Focus by Drug Class 161
17.4.3 Marketed Product Portfolio 162
17.4.4 R&D Pipeline Analysis 163
17.4.5 Strategic and Growth Analysis 163
17.5 Gilead Sciences 164
17.5.1 Overview 164
17.5.2 Sales Focus by Drug Class 164
17.5.3 Marketed Product Portfolio 165
17.5.4 R&D Pipeline Analysis 165
17.5.5 Strategic and Growth Analysis 166
17.6 Abbott 166
17.6.1 Overview 166
17.6.2 Sales Focus by Drug Class 166
17.6.3 Marketed Product Portfolio 167
17.6.4 R&D Pipeline Analysis 167
17.6.5 Strategic and Growth Analysis 168
17.7 Wyeth (Acquired by Pfizer) 168
17.7.1 Overview 168
17.7.2 Sales Focus by Drug Class 168
17.7.3 Marketed Product Portfolio 169
17.7.4 R&D Pipeline Analysis 169
17.7.5 Strategic and Growth Analysis 170
17.8 Sanofi-Aventis 170
17.8.1 Overview 170
17.8.2 Sales Focus by Drug Class 170
17.8.3 Marketed Product Portfolio 171
17.8.4 R&D Pipeline Analysis 172
17.8.5 Strategic and Growth Analysis 172
17.9 Bristol-Myers Squibb 173
17.9.1 Overview 173
17.9.2 Sales Focus by Drug Class 173
17.9.3 Marketed Product Portfolio 173
17.9.4 R&D Pipeline Analysis 173
17.9.5 Strategic and Growth Analysis 174
17.10 Johnson & Johnson 174
17.10.1 Overview 174
17.10.2 Sales Focus by Drug Class 175
17.10.3 Marketed Product Portfolio 175
17.10.4 R&D Pipeline Analysis 175
17.10.5 Strategic and Growth Analysis 176
17.11 Roche Pharma AG 176
17.11.1 Overview 176
17.11.2 Sales Focus by Drug Class 177
17.11.3 Marketed Product Portfolio 177
17.11.4 R&D Pipeline Analysis 177
17.11.5 Strategic and Growth Analysis 177

18. Company Profiles 179
18.1 Abraxis BioScience, Inc. 179
18.2 Acambis (now Sanofi Pasteur) 179
18.3 Achillion Pharmaceuticals, Inc. 179
18.4 Adlyfe, Inc. 180
18.5 Advanced Life Sciences Holdings, Inc. 181
18.6 Affinium Pharmaceuticals 181
18.7 Akonni Biosystems 181
18.8 Alnylam Pharmaceuticals 181
18.9 APP Pharmaceuticals 182
18.10 Aquapharm Biodiscovery 182
18.11 Arbor Vita Corporation 182
18.12 Arpida Ltd. (Now Evolva) 183
18.13 Avexa Ltd. 183
18.14 Basilea Pharmaceutica AG 183
18.15 Baxter International, Inc. 183
18.16 Biophage Pharma, Inc. 184
18.17 CEL-SCI Corporation 184
18.18 Cerexa, Inc. (Subsidiary of Forest Laboratories) 185
18.19 CombiMatrix Corporation 185
18.20 Cubist Pharmaceuticals, Inc. 185
18.21 Daiichi Sankyo Co., Ltd. 186
18.22 Hospira, Inc. 186
18.23 Incyte Corporation 187
18.24 Idenix Pharmaceuticals, Inc. 187
18.25 Medivir AB 188
18.26 Meiji Holdings Co., Ltd. 188
18.27 MerLion Pharma 189
18.28 Mutabilis 189
18.29 NanoBio Corporation 189
18.30 Nanosphere, Inc. 190
18.31 NanoViricides, Inc. 190
18.32 Novabay Pharmaceuticals, Inc. 190
18.33 Obetech, LLC 191
18.34 Optimer Pharmaceuticals, Inc. 191
18.35 Panacos Pharmaceuticals, Inc. 192
18.36 Paratek Pharmaceuticals, Inc. 192
18.37 Pharmasset, Inc. 192
18.38 Pico Pharmaceuticals, Inc. 193
18.39 PolyMedix, Inc. 193
18.40 PowderMed Ltd. (Subsidiary of Pfizer) 193
18.41 Presidio Pharmaceuticals, Inc. 194
18.42 Progenics Pharmaceuticals, Inc. 194
18.43 Protez Pharmaceuticals (a Novartis Subsidiary) 194
18.44 Ribomed Biotechnologies, Inc. 195
18.45 Rib-X Pharmaceuticals, Inc. 195
18.46 Targanta Therapeutics Corporation, Inc. (Acquired by The Medicine Company) 195
18.47 Theravance, Inc. 196
18.48 Trius Therapeutics 196
18.49 Vertex Pharmaceuticals, Inc. 196
18.50 X-GEN Pharmaceuticals, Inc. 197

Appendix 1: FDA Compliance Policies Regarding Approved New Drug and Antibiotic Drug Products 198
Appendix 2: Anti-HCV Drugs in Development 200
Appendix 3:Market for Anti-Infectives in Animal Health 203
Appendix 4: Diagnostics for Infectious Agents 209
[Inhaltsverzeichnis ausblenden]

Table 1.1: Top Ten Causes of Death Worldwide 12
Table 1.2: Leading Pharmaceutical Companies in the Anti-Infective Market, 2009 16
Table 2.1: Annual Rates of Global Infectious Diseases 21
Table 2.2: Drugs in Development for Chronic Hepatitis B, 2010 40
Table 2.3: Global HIV Statistics, 2008 50
Table 3.1: Top Selling Anti-Infective Drugs, 2008 59
Table 3.2: Sales for Leading Companies' Infectious Diseases Segments, 2008 60
Table 3.3: Current Drug Development Times and Rates by Therapeutic Indication 61
Table 3.4: Emerging Therapeutic Approaches 61
Table 3.5: New Drug Approvals in All Categories from FDA, 2000-2009 62
Table 3.6: Top Ten Global Pharmaceutical Markets, 2008 63
Table 3.7: BRIC Countries, Percentage of GDP Spent on Healthcare, 2008 63
Table 3.8: Percentage of GDP Healthcare Spending by Country, 2008 64
Table 3.9: Top 20 Generic Drugs by Prescriptions, 2008 67
Table 3.10: Anti-Bacterial Agents Undergoing Clinical Development 68
Table 3.11 Leading Tuberculosis R&D Candidates 69
Table 3.12: Pipeline for Repositioned Drugs 69
Table 4.1: Potential Anti-Bacterial Protein Drug Targets 74
Table 4.2: In vitro Susceptibility of Staphylococci to New Agents in Development 74
Table 4.3: Anti-Staphylococcal Vaccines and Immunoglobulins in the Late Stage Pipeline, 2009 75
Table 4.4: Bacterial Targets of Antibiotics and Resistance Mechanisms 75
Table 4.5: Guideline Summary for Antibiotic Selection for Skin and Soft Tissue Infections 76
Table 4.6: Selected Anti-Viral Drugs 84
Table 4.7: Anti-Reterovirals in Development, 2008 84
Table 4.8: New Types of HIV Drugs 85
Table 4.9: Recommended Daily Dosage of Seasonal Influenza Anti-Viral Medications for Treatment and Chemoprophylaxis in the U.S., 2008-2009 86
Table 4.10: Percentage Drug Resistance for Common Influenza Virus Strains, 2009 87
Table 4.11: Selected HCV Drugs in Development, 2009 88
Table 4.12: Therapeutic Agents in Development for Treating Hepatitis B, 2008 89
Table 4.13: Anti-Fungal Compounds in Late Stage Development 90
Table 4.14: New Vaccines Licensed, 2005-2010 92
Table 4.15: Global Top Selling Blockbuster Vaccines, 2008 96
Table 4.16: Selected Anti-Infective Monoclonal Antibodies in Clinical Development, 2009 96
Table 5.1: FDA-approved Commercial Kits for the Detection of Infectious Agents 98
Table 5.2: Examples of Personalized Medicine in Treatment of Infectious Disease 99
Table 6.1: Competitive Landscape for Anti-Viral Drugs in Development, 2009 103
Table 6.2: Competitive Landscape for Antibiotic Drugs in Development, 2009 103
Table 8.1 Anti-HIV Therapeutics Approved by the FDA 110
Table 9.1: Major Classes of Antibiotics 112
Table 10.1: Major Classes of Anti-Fungals 118
Table 11.1: CCR-5 Receptor Agonists in Development, 2009 125
Table 12.1: Major Pathogens Identified in the Last 30 Years 130
Table 12.2: Emerging and Re-emerging Infectious Diseases and their Geographical Location 133
Table 16.1: Pharmaceutical Companies Ranked by Total R&D Expenditures, 2008 143
Table 16.2: International Regulatory Measures Indicated by the International Forum of Anti-Bacterial Resistance 145
Table A2.1: Anti-HCV Pipeline, 2009 200
Table A3.1: European Sales of Animal Health Antibiotics, 2005-2012 204
Table A3.2: Use of Antibiotics as Growth Promotants 206
Table A4.1: Market Structure for Infectious Disease Diagnostics 210
Table A4.2: Rapid Strep Tests on the Market 211
Table A4.3: Rapid Tests for Chlamydia 213
Table A4.4: Rapid Tests for Gonorrhea 215
Table A4.5: Burden of Influenza 216
Table A4.6: Global Market Potential for TB Diagnostic Testing, 2000-2010 221
Table A4.7: Global Market for HBV Diagnostic Testing, 2000-2012 224
Table A4.8: U.S. Market for HBV Diagnostic Testing, 2000-2012 224
Table A4.9: Serological Diagnosis of Hepatitis B Virus Infections 226
Table A4.10: Lower Detection Limits of HBV DNA Assays 227
Table A4.11: Type of Test: Lateral Flow 230
Table A4.12: Type of Test: Flow-through 231
Table A4.13: Type of Test: Agglutination 231
Table A4.14: Type of Test: Immunoblot 231
Table A4.15: Global Market for HCV Diagnostic Testing, 2000-2009 234
Table A4.16: Efficiency of Available HCV Screening Tests 235
Table A4.17: Recommendations for Diagnostic Testing for Hepatitis C 237
Figure 1.1: Leading Causes of Death in the U.S., 1961-2007 12
Figure 1.2: Global Distribution of Anti-Infective Drugs Sales by Geography 15
Figure 2.1: Incidence Rates of Invasive MRSA Infections by Age 20
Figure 2.2: U.S. Child Death Rate from Preventable Diseases, 2007 22
Figure 2.3: Infection Rate of Serotype 19A by Age Group in the U.S., 1998-2006 27
Figure 2.4: U.S. Hospitalizations for Types of Respiratory Diseases in Children Under 15 Years of Age 27
Figure 2.5: Economic Burden of Select Lung Diseases in the U.S., 2007 28
Figure 2.6: Infection Rate of Invasive Pneumococcal Disease in the U.S., 1998-2007 28
Figure 2.7: Status of H5N1 Avian Influenza, 2009 29
Figure 2.8: Number of Reported and Confirmed Cases of Influenza H1N1 Strain Worldwide, 2009 31
Figure 2.9: Distribution of H1N1 Flu in the U.S., May 22, 2010 32
Figure 2.10: Novel H1N1 Confirmed and Probable Case Rate in the U.S. by Age Group 32
Figure 2.11: Number of Tuberculosis Cases Among U.S.-born and Foreign-born Persons by Year Reported in the U.S., 1993-2009 34
Figure 2.12: Rate of Tuberculosis Cases Among U.S.-born and Foreign-born Persons by Year Reported in the U.S., 1993-2009 34
Figure 2.13: Rate of Tuberculosis Cases by State/Area in the U.S., 2009 35
Figure 2.14: U.S.-born Tuberculosis Cases by Ethnicity, 2008 36
Figure 2.15: Rate of New Hepatitis A, B and C Infections in the U.S., 1982-2007 39
Figure 2.16: Countries Reporting Outbreaks of Cholera, 2007-2009 42
Figure 2.17: U.S. Rates of Sexually-Transmitted Diseases, 1940-2008 43
Figure 2.18: Rate of New Cases and Deaths of Cervical Cancer by Age Group Worldwide, 2008 45
Figure 2.19: Global Trend of HIV Infection, 1991-2008 48
Figure 2.20: Worldwide Percentage of Adults Living with HIV, 1990-2006 48
Figure 2.21: Worldwide Rate of New HIV Cases, 1990-2008 49
Figure 2.22: Percentage of Adult Population in African Countries with HIV, 2007 49
Figure 2.23: Ethnic Distribution of AIDS Patients in the U.S., 2007 51
Figure 2.24: Ten Best Selling AIDS Drugs in the U.S., 2009 51
Figure 2.25: U.S. Rates for New HIV Cases, 2008 52
Figure 2.26: Global Malaria-Endemic Areas in the Eastern Hemisphere 54
Figure 2.27: Anti-Malarial Vaccine Pipeline, 2009 55
Figure 2.28: Global Anti-Malarial Drug Pipeline, 2008 56
Figure 2.29: West Nile Virus Activity in the U.S., 2009 57
Figure 3.1: Anti-Infective Drugs Market Projections, 2006-2013 58
Figure 3.2: Leading Companies in Anti-Infectives Market Share, 2008 59
Figure 3.3: Number of New Anti-Bacterial Agents Approved by the FDA in the U.S., 1983-2008 62
Figure 3.4: Total Spending on Healthcare in the U.S., 1960-2008 64
Figure 3.5: Percentage Breakdown of U.S. Healthcare Spending, 2008 65
Figure 3.6: International per Capita Healthcare Spending by Country, 2008 65
Figure 3.7: Generic Drug Applications and Approvals in the U.S., 1995-2006 66
Figure 3.8: Savings Generated by Generic Use in the U.S. by Therapeutic Category, 1999-2008 67
Figure 3.9: Anti-Bacterial and Anti-HIV New Molecular Entities (NMEs) Approved by the FDA, 1993-2007 70
Figure 3.10: Cost for New Drugs by Primary Indication, 2007 71
Figure 4.1: Market Share by Leading Anti-Bacterial Drug Class 73
Figure 4.2: Anti-Virals in the Marketplace 82
Figure 4.3: Anti-Virals Market by Indication, Excluding HIV and HCV 83
Figure 4.4: Anti-Viral Therapeutics Market by Drug Class 84
Figure 4.5: Global Distribution of the Lack of Childhood Vaccination 92
Figure 4.6: GAVI Alliance Members 93
Figure 4.7: Global Vaccines Market, 2008 94
Figure 4.8: GlaxoSmithKline's Vaccine Pipeline, 2008 95
Figure 4.9: Vaccine Market by Geographical Area, 2008 95
Figure 5.1: Global Market for Molecular Diagnostics, 2002-2013 98
Figure 6.1: Number of Non-elderly Americans without Health Insurance Coverage, 1994-2008 102
Figure 6.2: Percentage of Non-elderly Americans without Health Insurance Coverage, 1994-2008 102
Figure 7.1: Global Multidrug Susceptibility in P. aeruginosa 106
Figure 7.2: Global Frequency of Vancomycin-resistant Enterococci, 2006 106
Figure 7.3: MRSA Trends According to Patient Location, 1998-2005 107
Figure 9.1: Market for Injectable Anti-Bacterials, 2008 and 2013 113
Figure 9.2: Market Share for Major Anti-Bacterial Classes, 2008 and 2013 113
Figure 9.3: Frequency of S. aureus in Skin and Soft Tissue Infections 116
Figure 11.1: Current and Projected Market Size for Injectable Antiretrovirals by Class, 2008 and 2013 121
Figure 11.2: Market Share for Injectable Antiretrovirals by Drug Class, 2008 122
Figure 11.3: HCV Market: Growth and Projections by Drug Class, 2008 and 2013 126
Figure A3.1: Growth in Global Sales of Antibiotic Products in Animal Health, 2005-2012 203
Figure A4.1: FIND Pipeline for TB Diagnostics 219
[Tabellenverzeichnis ausblenden]