Epidemiology: Hepatocellular Cancer

Introduction

Datamonitor estimates that 88,300 incident cases of hepatocellular cancer will occur in the seven major markets in 2010. This number is forecast to rise by 3% to 90,800 by 2020. Annual incident hepatocellular cases will increase in the US (49%) and each of the five major EU markets (France, Germany, Italy, Spain, and the UK) (20-28%). However, Japan will see a 25% decrease.
Features and benefits

* Gain insight to market potential including a robust 10-year epidemiology forecast of hepatocellular cancer incident cases.* Understand the key epidemiologic risk factors associated with hepatocellular cancer.
Highlights

In 2008, liver cancer was the fifth most commonly diagnosed cancer among men (522,000 cases) and the seventh most commonly diagnosed cancer among women (225,000 cases) worldwide. It is the 17th most commonly diagnosed cancer in the developed world and the fifth most commonly diagnosed cancer in the developing world.Hepatocelluar cancer is primarily due to hepatitis C infection, but also hepatitis B and alcohol. The hepatitis C epidemic began in the 1940s in Japan, driving the sharp increase in incident hepatocellular cancer cases that began in the 1970s and peaked in the 1990s in this market. The US and EU follow Japan by approximately 20 years in this trend.
Your key questions answered

* What are the most robust sources for hepatocellular cancer incidence data?* How will the patient population change over the next decade in the US, Japan, and five major EU markets (France, Germany, Italy, Spain, and the UK)?* What are the major risk factors for hepatocellular cancer that drive the trend in incident cases and how are they changing?

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Executive Summary
Disease burden overview
Forecast results (2010–20)
Stage and Child-Pugh distributions for 2010
OVERVIEW
Catalyst
Summary
DISEASE DEFINITION AND DIAGNOSIS CRITERIA
Definition of hepatocellular cancer
GLOBAL VARIATION AND HISTORICAL TRENDS
Incidence varies across seven major healthcare markets
RISK FACTORS
Environmental risk factors
Hepatitis B virus (HBV)
Hepatitis C virus (HCV)
Alcohol
Aflatoxin
Tobacco
Host risk factors
Demographic risk factors
Male sex
Race and Ethnicity
EPIDEMIOLOGIC FORECASTING OF HEPATOCELLULAR CANCER
Sources of epidemiologic data
Cancer registries: age- and country-specific incidence rates
Population denominators
Description of methods
Incidence forecasting
US
Japan
France
Germany
Italy
Spain
UK
Age
Stage
US
Japan
France
Germany
Italy
Spain
UK
Child-Pugh class
US
Japan
France
Germany
Italy
Spain
UK
EPIDEMIOLOGIC RESULTS
Estimated incident cases of hepatocellular cancer and future trends
Segmentation of incident cases: 2010
DISCUSSION
US
Japan
EU
BIBLIOGRAPHY
Journal papers
Websites
APPENDIX A
Module methodology

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