TABLE OF CONTENTS
Overview 1
Catalyst 1
Summary 1
About Datamonitor Healthcare 2
About the Oncology pharmaceutical analysis team 2
Executive Summary 3
Strategic scoping and focus 3
Datamonitor insight into the breast, ovarian, and cervical cancer markets 3
Contributing experts 4
Related reports 5
Upcoming reports 5
1. Pipeline Overview and Dynamics 9
Key findings 9
Pipeline summary: breast cancer 10
Pipeline summary: ovarian cancer 13
Pipeline summary: cervical cancer 16
2. R&D Approach 17
Key findings 17
Clinical trial design in cancer 17
3. Epidemiology 21
Introduction 21
Key points 21
Epidemiologic forecasting of breast, ovarian, and cervical cancers 23
Epidemiologic results: breast cancer 27
Epidemiologic results: ovarian cancer 35
Epidemiologic results: cervical cancer 39
Strengths of Datamonitor's epidemiologic projections 44
Conclusions 44
4. Market Overview: Breast Cancer 45
Disease definition 45
Patient segmentation 46
Current treatment options 50
Unmet needs in breast cancer 56
Target product profile versus current level of attainment 59
5. Pipeline Analysis and Forecasts: Breast Cancer 61
Afatinib (BIBW-2992; Boehringer Ingelheim) 67
Afinitor (everolimus; Novartis) 72
Halaven (eribulin mesylate; Eisai) 81
Iniparib (BSI-201; BiPar Sciences/Sanofi-Aventis) 90
Neratinib (HKI-272; Pfizer) 98
Omnitarg (pertuzumab; Genentech/Roche/Chugai) 104
Ramucirumab (IMC-1121B; Eli Lilly) 113
Trastuzumab-DM1 (ImmunoGen/Genentech/Roche/Chugai) 119
Votrient (pazopanib; GlaxoSmithKline) 127
6. Market Overview: Ovarian Cancer 135
Definition 135
Current treatment options 140
Target product profile versus current level of attainment 155
7. Pipeline Analysis and Forecasts: Ovarian Cancer 157
Abagovomab (ACA-125; Menarini/CellControl BioMedical) 162
AMG 386 (Amgen) 168
Avastin (bevacizumab; Genentech/Roche/Chugai) 174
Farletuzumab (MORAb-003; Morphotek/Eisai) 186
Karenitecin (cositecan; BNP-1350; BioNumerik) 193
Tarceva (erlotinib; Genentech/Roche/Chugai/OSI) 199
Vargatef (intedanib/BIBF-1120; Boehringer Ingelheim) 205
Votrient (pazopanib; GlaxoSmithKline) 210
Olaparib (AZD2281; AstraZeneca) 218
8. Market Overview Cervical Cancer 222
Disease definition 222
Patient segmentation 223
Current treatment options 227
Target product profile versus current level of attainment 234
Bibliography 236
Chapter 1: Pipeline Overview and Dynamics 236
Chapter 2: R&D approach 236
Chapter 3: Epidemiology 237
Chapter 4: Market Overview: Breast Cancer 239
Chapter 5: Pipeline Analysis & Forecasts: Breast Cancer 243
Chapter 6: Market Overview: Ovarian Cancer 246
Chapter 7: Pipeline Analysis and Forecasts: Ovarian Cancer 251
Chapter 8: Market Overview: Cervical Cancer 254
Appendix 258
Abbreviations 258
Methodology 258
About Datamonitor 264
Datamonitor consulting 265
Disclaimer 265
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